In accordance with its mission to support high level research in Belgium, the University Foundation provides financial support towards the publication in high level international journals of scientific papers which report on research in Belgian research groups. Financial support may be granted to partially cover the costs due by the author for illustrations, for page charges and for article processing fees, and for linguuistic control.
What follows is a list of articles that were subsidized recently by the University Foundation. The titles are ordered by year of publication and by title.
Tosenberger, A. et al. (2017) A multiscale model of early cell lineage specification including cell division, npj Systems Biology and Applications (2017) 3:16 ; doi:10.1038/s41540-017-0017-0.
Embryonic development is a self-organised process during which cells divide, interact, change fate according to a complex gene regulatory network and organise themselves in a three-dimensional space. Here, we model this complex dynamic phenomenon in the context of the acquisition of epiblast and primitive endoderm identities within the inner cell mass of the preimplantation embryo in the mouse. The multiscale model describes cell division and interactions between cells, as well as biochemical reactions inside each individual cell and in the extracellular matrix.
EEG dominant frequency peak differentiates between Alzheimer’s disease and frontotemporal lobar degeneration
Goossens, J. et al (2017) EEG dominant frequency peak differentiates between Alzheimer’s disease and frontotemporal lobar degeneration. Journal of Alzheimer’s Disease vol. 55 pp. 53-58.
We investigated the power of EEG as biomarker in differential diagnosis of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). EEG was recorded from 106 patients with AD or FTLD, of which 37 had a definite diagnosis, and 40 controls. Dominant frequency peaks were extracted for all 19 channels, for each subject. The average frequency of the largest dominant frequency peaks (maxpeak) was significantly lower in AD than FTLD patients and controls. Based on ROC analysis, classification could be made with diagnostic accuracy of 78.9%.
From the 8-Hour Day to the 40-Hour Week: Legitimization Discourses of Labour Legislation between the Wars in France and Belgium
Rudischhauser, S. (2017) From the 8-Hour Day to the 40-Hour Week: Legitimization Discourses of Labour Legislation between the Wars in France and Belgium. Politics and Governance, Volume 5, Issue 1, Pages 6–14.
In the interwar period both France and Belgium passed legislation reducing the number of working hours and established a hybrid regulatory regime lending a certain degree of official authority to collective agreements. The paper analyses discourses by scholars who, as experts, were close to the political elites, and who tried to legitimize this kind of co-regulation by pointing out the inefficiency of state intervention and the epistemic authority of non-state actors.
Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells
Van Audenaerde, JRM et al. (2017) Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells. Oncotarget.
Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancerrelated death in Western countries with a 5-year survival rate below 5%. One of the hallmarks of this cancer is the strong desmoplastic reaction within the tumor microenvironment (TME), orchestrated by activated pancreatic stellate cells (PSC). This results in a functional and mechanical shield which causes resistance to conventional therapies.
Gonze, D. et al. (2017) Multi-stability and the origin of microbial community types. The ISME Journal (doi:10.1038/ismej.2017.60)
The study of host-associated microbial community composition has suggested the presence of alternative community types. We discuss three mechanisms that could explain these observations. The most commonly invoked mechanism links community types to a response to environmental change; alternatively, community types were shown to emerge from interactions between members of local communities sampled from a metacommunity. Here, we emphasize multi-stability as a third mechanism, giving rise to different community types in the same environmental conditions.
No added diagnostic value of nonphosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis
Goossens, J. et al. (2017) No added diagnostic value of nonphosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis. Alzheimer's Research & Therapy 9:49
Background: The Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers Aβ1–42, t-tau, and p-tau181 overlap with other diseases. New tau modifications or epitopes, such as the non-phosphorylated tau fraction (p-taurel), may improve differential dementia diagnosis. The goal of this study is to investigate if p-taurel can improve the diagnostic performance of the AD CSF biomarker panel for differential dementia diagnosis.
Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy
Jacobs, J. at al. (2017) Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy. Oncotarget.
In contrast to the negligible expression of the immunomodulating protein CD70 in normal tissue, we have demonstrated constitutive overexpression of CD70 on tumor cells in a subset of primary non-small cell lung cancer (NSCLC) biopsies. This can be exploited by CD70-targeting antibody-dependent cellular cytotoxicity (ADCC)-inducing antibodies. Early clinical trials of these antibodies have already shown promising results in CD70-positive malignancies. In this study, we explored the potential of cisplatin to induce CD70 expression in NSCLC.
Desender, K. et al. (2017) Subjective experience of difficulty depends on multiple cues. Sci. Rep. 7, 44222; doi: 10.1038/srep44222.
Human cognition is characterized by subjective experiences that go along with our actions, but the nature and stability of these experiences remain largely unclear. In the current report, the subjective experience of difficulty is studied and it is proposed that this experience is constructed by integrating information from multiple cues.
The Desire of Parenthood: Intuitive Co-parental Behaviors and Quality of Couple Relationship among Italian and Belgian Same-Sex and Opposite-Sex Couples
Miscioscia M et al. (2017) The Desire of Parenthood: Intuitive Co-parental Behaviors and Quality of Couple Relationship among Italian and Belgian Same-Sex and Opposite-Sex Couples. Front. Psychol. 8:110. doi: 10.3389/fpsyg.2017.00110
Studies that focused on family issues have allowed a great understanding of the aspects related to its subsystems, such as parenting desire and its expectations, couples’ satisfaction and quality of child’s outcomes. All these aspects are greatly interconnected and contribute to the creation of specific family dynamics, such as the quality of family interactions. The present study focuses on intuitive co-parental behaviors and the quality of couple relationship observed during the decision process (intention and desire) to be (or become) parents.
A Comparative Study of Microleakage on Dental Surfaces Bonded with Three Self-Etch Adhesive Systems Treated with the Er:YAG Laser and Bur
El HaddarY.S., Cetik S., Bahrami, B., and Atash R. (2016) A Comparative Study of Microleakage on Dental Surfaces Bonded with Three Self-Etch Adhesive Systems Treated with the Er:YAG Laser and Bur, BioMed Research International, vol. 2016, Article ID 2509757, 6 pages, doi:10.1155/2016/2509757
This study sought to compare the microleakage of three adhesive systems in the context of Erbium-YAG laser and diamond bur cavity procedures. Cavities were restored with composite resin.
Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome
Van Driessche, B. et al. (2016) Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome. Sci. Rep. 6, 31125.
Bovine leukemia virus latency is a viral strategy used to escape from the host immune system and contribute to tumor development. However, a highly expressed BLV micro-RNA cluster has been reported, suggesting that the BLV silencing is not complete. Here, we demonstrate the in vivo recruitment of RNA polymerase III to the BLV miRNA cluster both in BLV-latently infected cell lines and in ovine BLV-infected primary cells, through a canonical type 2 RNAPIII promoter.
Effects of 12 weeks of aerobic or strength training in addition to standard care in Parkinson's disease
Demonceau, M. et al. (2016) Effects of 12 weeks of aerobic or strength training in addition to standard care in Parkinson's disease. European Journal of physical and rehabilitation medicine
BACKGROUND: Physical exercises in addition to standard care (SC) in patients with Parkinson’s disease (PD) are now common practice in many care units. However, exercises can cover a wide range of interventions, and the specific effects of different interventions still deserve to be further investigated.
AIM: To compare the effects of 12 weeks of two different types of physical exercises with SC in patients suffering from PD.
DESIGN: Pseudo-randomized controlled trial.
SETTING: University laboratory for outcomes, University Hospital Centre for interventions.
Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells
Lub, S. et al. (2016) Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells, Oncotarget, vol. 7, n° 4.
The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase involved in cell cycle. During the metaphase-anaphase transition the APC/C is activated by Cdc20. The aim of this study is to elucidate the importance and therapeutic potential of APC/C and its co-activator Cdc20 in multiple myeloma (MM). Gene expression analysis revealed that Cdc20 was expressed at higher levels in gene expression-based high-risk MM patients. Moreover, high Cdc20 expression correlated with poor prognosis.
Otero, V.; Quisthoudt, K.; Koedam, N.; Dahdouh-Guebas, F. (2016) Mangroves at Their Limits: Detection and Area Estimation of Mangroves along the Sahara Desert Coast. Remote Sensing, 8, 512.
The northernmost and most arid mangrove ecosystem ofWest Africa is found in Mauritania, in the Parc National du Banc d’Arguin (PNBA). The existing global and regional maps of Mauritania’s mangroves have little detail, and available estimates of the mangrove area differ among studies. We assessed the use of automated Remote Sensing classification techniques to calculate the extent and map the distribution of the mangrove patches located at Cap Timiris, PNBA, using QuickBird and GeoEye imagery.
Rhizophoraceae mangrove saplings use hypocotyl and leaf water storage capacity to cope with soil water salinity changes
Lechthaler, S. et al. (2016) Rhizophoraceae mangrove saplings use hypocotyl and leaf water storage capacity to cope with soil water salinity changes. Frontiers in Plant Science, 2016, issue 00895,
Some of the most striking features of Rhizophoraceae mangrove saplings are their voluminous cylinder-shaped hypocotyls and thickened leaves. The hypocotyls are known to serve as floats during seed dispersal (hydrochory) and store nutrients that allow the seedling to root and settle. In this study we investigate to what degree the hypocotyls and leaves can serve as water reservoirs once seedlings have settled, helping the plant to buffer the rapid water potential changes that are typical for the mangrove environment.