Articles Scientifiques

La Fondation Universitaire peut accorder des subsides pour promouvoir la publication d'articles scientifiques dans des revues internationales.

Articles scientifiques, subventionnés par la Fondation Universitaire

Ce qui suit est une liste d'articles scientifiques qui ont été subventionnés par la Fondation Universitaire. Les articles sont triés par année de publication et par titre.

Koenraad Philippaert, Sara Kerselaers, Thomas Voets and Rudi Vennekens

Philippaert, K. et al. (2018)  A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels. SLAS Discovery.

TRPM5 functions as a calcium-activated monovalent cation-selective ion channel and is expressed in a variety of cell types. Dysfunction of this type of channel has been recently implied in cardiac arrhythmias, diabetes, and other pathologies. Therefore, a growing interest has emerged to develop the pharmacology of these ion channels. We optimized a screening assay based on the thallium flux through the TRPM5 channel and a fluorescent thallium dye as a probe for channel activity.

Nathalie Biset et al.

Biset, N. et al. (2018)  Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill dataPatient Preference and Adherence 12 153–161.

Purpose: The aims of the study were to evaluate medication adherence and the influencing factors for isotretinoin and contraception (oral, patches, and rings) and to evaluate the concomitant use of contraception and isotretinoin.

Joni Gilissen et al.

Gilissen, J. et al. How to achieve the desired outcomes of advance care planning in nursing homes: a theory of change BMC Geriatrics (2018, 18:47 DOI 10.1186/s12877-018-0723-5.

Background: Advance care planning (ACP) has been identified as particularly relevant for nursing home residents, but it remains unclear how or under what circumstances ACP works and can best be implemented in such settings. We aimed to develop a theory that outlines the hypothetical causal pathway of ACP in nursing homes, i.e. what changes are expected, by means of which processes and under what circumstances.
Jorrit De Waele et al.

Dewaele, J. et al.  (2018) Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade. OncoImmunology, vol. 7 no 3.

Prognosis of glioblastoma remains dismal, underscoring the need for novel therapies. Immunotherapy is generating promising results, but requires combination strategies to unlock its full potential. We investigated the immunomodulatory capacities of poly(I:C) on primary human glioblastoma cells and its combinatorial potential with programmed death ligand (PD-L) blockade. In our experiments, poly(I:C) stimulated expression of both PD-L1 and PD-L2 on glioblastoma cells, and a pro-inflammatory secretome, including type I interferons (IFN) and chemokines CXCL9, CXCL10, CCL4 and CCL5.

C. B. Calderon et al.

Calderon, C.B. (2018) Task-Relevant Information Modulates Primary Motor Cortex Activity Before Movement Onset.Frontiers in Human Neuroscience,Volume 12, Article 93.

Monkey neurophysiology research supports the affordance competition hypothesis (ACH) proposing that cognitive information useful for action selection is integrated in sensorimotor areas. In this view, action selection would emerge from the simultaneous representation of competing action plans, in parallel biased by relevant task factors.
Alen Tosenberger, Didier Gonze, Sylvain Bessonnard, Michel Cohen-Tannoudji, Claire Chazaud & Geneviève Dupont

Tosenberger, A. et al.  (2017) A multiscale model of early cell lineage specification including cell division, npj Systems Biology and Applications (2017) 3:16 ; doi:10.1038/s41540-017-0017-0.

Embryonic development is a self-organised process during which cells divide, interact, change fate according to a complex gene regulatory network and organise themselves in a three-dimensional space. Here, we model this complex dynamic phenomenon in the context of the acquisition of epiblast and primitive endoderm identities within the inner cell mass of the preimplantation embryo in the mouse. The multiscale model describes cell division and interactions between cells, as well as biochemical reactions inside each individual cell and in the extracellular matrix.

Isabelle Houbracken & Luc Bouwens

Houbracken, I. and Bouwens, L. (2017) Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cellsScientific Reports 7, Article number: 12643. doi:10.1038/s41598-017-12721-9.

Pancreatic acinar cells secrete digestive enzymes necessary for nutrient digestion in the intestine. They are considered the initiating cell type of pancreatic cancer and are endowed with differentiation plasticity that has been harnessed to regenerate endocrine beta cells. However, there is still uncertainty about the mechanisms of acinar cell formation during the dynamic period of early postnatal development.

Joery GOOSSENS et al.

Goossens, J. et al (2017) EEG dominant frequency peak differentiates between Alzheimer’s disease and frontotemporal lobar degeneration. Journal of Alzheimer’s Disease vol. 55 pp. 53-58.

We investigated the power of EEG as biomarker in differential diagnosis of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). EEG was recorded from 106 patients with AD or FTLD, of which 37 had a definite diagnosis, and 40 controls. Dominant frequency peaks were extracted for all 19 channels, for each subject. The average frequency of the largest dominant frequency peaks (maxpeak) was significantly lower in AD than FTLD patients and controls. Based on ROC analysis, classification could be made with diagnostic accuracy of 78.9%.

Anne Fromont et al.

Fromont, A. et al.  (2017) Exploring the validity of scores from the Rosenberg Self-Esteem Scale (RSES) in Burundi: A multi-strategy approach.  Journal of Psychology in Africa, Vol. 27, no.4, pp. 316-324.

The present study aimed to validate the Rosenberg Self-Esteem Scale (RSES) in Burundi, through a multi-strategy approach used in cross-cultural studies. Respondents were 906 health workers (men =56%; caregivers 60%). They responded to a bilingual version of RSES. We utilized Confirmatory Factorial Analysis (CFA) with structural equation modelling and a back translation test to explore the structure of the RSES and the reliability of scores from the scale.

Kim De Veirman et al.

De Veirman, K. et al. (2018) Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion.  Cancer Immunol Res. 5(10), 839–46. 

Dysregulated expression of S100 protein family members is associated with cancer proliferation, invasion, angiogenesis, and inflammation. S100A9 induces myeloid-derived suppressor cell (MDSC) accumulation and activity. MDSCs, immunosuppressive cells that contribute to tumor immune escape, are the main producers of S100A9.
Sabine Rudischhauser

Rudischhauser, S. (2017) From the 8-Hour Day to the 40-Hour Week: Legitimization Discourses of Labour Legislation between the Wars in France and Belgium. Politics and Governance, Volume 5, Issue 1, Pages 6–14.

In the interwar period both France and Belgium passed legislation reducing the number of working hours and established a hybrid regulatory regime lending a certain degree of official authority to collective agreements. The paper analyses discourses by scholars who, as experts, were close to the political elites, and who tried to legitimize this kind of co-regulation by pointing out the inefficiency of state intervention and the epistemic authority of non-state actors.

Jonas R.M. Van Audenaerde et al.

Van Audenaerde, JRM et al. (2017) Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells.  Oncotarget.

Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancerrelated death in Western countries with a 5-year survival rate below 5%. One of the hallmarks of this cancer is the strong desmoplastic reaction within the tumor microenvironment (TME), orchestrated by activated pancreatic stellate cells (PSC). This results in a functional and mechanical shield which causes resistance to conventional therapies.

Lorenz Demey & Hans Smessaert

Demey, L & Smessaert, H. Logical and Geometrical Distance in Polyhedral Aristotelian Diagrams in Knowledge Representation. Symmetry 20179(10), 204.

Aristotelian diagrams visualize the logical relations among a finite set of objects. These diagrams originated in philosophy, but recently, they have also been used extensively in artificial intelligence, in order to study (connections between) various knowledge representation formalisms. In this paper, we develop the idea that Aristotelian diagrams can be fruitfully studied as geometrical entities. In particular, we focus on four polyhedral Aristotelian diagrams for the Boolean algebra B4, viz.

Didier Gonze, Leo Lahti, Jeroen Raes & Karoline Faust

Gonze, D. et al. (2017) Multi-stability and the origin of microbial community types.  The ISME Journal (doi:10.1038/ismej.2017.60)

The study of host-associated microbial community composition has suggested the presence of alternative community types. We discuss three mechanisms that could explain these observations. The most commonly invoked mechanism links community types to a response to environmental change; alternatively, community types were shown to emerge from interactions between members of local communities sampled from a metacommunity. Here, we emphasize multi-stability as a third mechanism, giving rise to different community types in the same environmental conditions.

Joery Goossens et al.

Goossens, J. et al. (2017) No added diagnostic value of nonphosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis. Alzheimer's Research & Therapy 9:49

Background: The Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers Aβ1–42, t-tau, and p-tau181 overlap with other diseases. New tau modifications or epitopes, such as the non-phosphorylated tau fraction (p-taurel), may improve differential dementia diagnosis. The goal of this study is to investigate if p-taurel can improve the diagnostic performance of the AD CSF biomarker panel for differential dementia diagnosis.