Heavy-metal-based nano-objects have been recently shown to act as radiosensitizers. One possible underlying mechanism causing this effect is the amplification of reactive oxygen species (ROS) production upon irradiation. This reaction could be utilized to improve radiotherapy by repolarizing M2 anti-inflammatory macrophages, which typically constitute the majority of the tumor-associated macrophage population, to the M1 pro-inflammatory phenotype that induces anti-cancer responses, as ROS upregulation has been associated with M1 polarization.

Relevant pre-clinical models are essential for driving progress in cancer therapy research. Here, we develop a pre-clinical study framework using an injectable orthotopic lung adenocarcinoma (LUAD) model (ORTHO) that replicates key features of human LUAD patients and is dissectible into tumoural and non-tumoural adjacent tissue, in analogy with patient samples. We also present SEPARATE-Seq, a broadly applicable technique enabling the partitioning of vascular and intratissue immune cells along with scRNA-Seq.

Background Antenatal and postnatal Group Care, based on the Centering Healthcare model, relies on three corecomponents: health assessment, interactive learning and community building. The health assessment consists of selfassessments conducted by the participants and one-to-one medical check-ups conducted by the healthcare provider. Research shows that this component can be challenging within existing health care systems.

Interferon-gamma release assays (IGRAs) have largely replaced the tuberculin skin test (TST) for diagnosing TB infection (TBI) in low-TB-burden countries, except in young children. This review assesses the diagnostic accuracy of IGRAs in children under 5 years old, using TST as a reference, for detecting TBI.

International migration is often driven by the desire to improve one’s well-being. For many, moving abroad represents a pathway to better economic opportunities, social conditions, or personal safety. Yet, not all individuals who aspire to migrate are able to do so. Involuntary immobility—a condition in which people wish to migrate but are constrained by external barriers such as legal restrictions, financial limitations, or lack of resources—may pose a significant challenge to subjective well-being.

Background Persons with disabilities generally have poorer oral health than persons without disabilities, which negatively affects their quality of life. As caregivers play an important role, this study investigated how oral health care is organised and performed by care staff in residential care settings, and examined the barriers and enablers they experience.

Mild cognitive impairment (MCI) is a high-risk state for dementia, marked by cognitive decline with preserved daily functioning. Combined physical and cognitive activity (PA+CA) programs show promising benefits for MCI patients. Involving adult children through intergenerational approaches may enhance participation and impact, yet little is known about tailoring such programs to both generations’ needs.